Investigation of the pathobiome in Alzheimer's disease

This research, conducted at Philadelphia College of Osteopathic Medicine (PCOM), seeks to advance understanding of how microbial communities—viruses, bacteria, fungi and parasites—may persist in the body, interact with the host, and drive inflammation, immune dysfunction and chronic neurodegenerative illness.

The Pathobiome Research Center (PBRC) serves as a hub for multi-institutional, interdisciplinary research focused on identifying microbial drivers of long-term disease and translating those discoveries into diagnostics, preventive strategies and precision-medicine approaches. This group has combined clinical and patient-centered insights with experimental rigor and contributed to pathobiome-driven discovery.