Optimization of Splenic Pump to Induce Translocation of Immune Cells from the Spleen to the Systemic Circulation

This research investigates how osteopathic manipulative techniques and neuromodulation influence systemic immune cell numbers, with a specific focus on the splenic pump. Conducted by a team of student researchers at Burrell College of Osteopathic Medicine and presented by Kathryn Cerami, OMS-II, the project entitled “Effect of Occipito-Atlantal Decompression, Transcutaneous Auricular Vagus Nerve Stimulation, and the Splenic Pump on Circulatory Immune Cell Numbers” earned first place in the student poster competition at the Osteopathic Medical Conference and Exposition (OMED).

The study explores the physiological interplay between osteopathic manipulative treatment (OMT) maneuvers—including splenic pump techniques—and neuromodulation of the vagus nerve, assessing their combined potential to mobilize immune cells from the spleen into the systemic circulation and to reduce inflammatory processes.

Nearly three million Americans live with chronic inflammatory diseases such as ulcerative colitis, Crohn’s disease, and rheumatoid arthritis. The Burrell research team framed their work within this clinical context, seeking nonpharmacologic approaches that might reduce inflammation or lower required drug dosages when used alongside standard therapies. Their results indicate that targeted OMT and vagus nerve neuromodulation can reduce markers of inflammation, suggesting these interventions may modulate immune function in clinically meaningful ways. The data supports the possibility that incorporating OMT and neuromodulation into treatment regimens could decrease medication doses and thereby reduce adverse effects associated with chronic drug use.

The study highlights the educational value of involving medical students in hands-on research under experienced mentorship, producing both scientific insight and professional development as demonstrated by the team’s recognition at a major national conference.